PUBLICATIONS
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Peer reviewed publications:
2011
Jean-Quartier, J., Bondarenko, A.I., Alam, M.R., Trenker, M., Waldeck-Weiermair, M., Malli, R., & Graier, W.F. Studying mitochondrial Ca2+ uptake - a revisit. Molecular and Cellular Endocrinology 2011 (in press) [Fulltext] [Pubmed]
Book: Store-operated Ca2+ entry (SOCE) pathways. Eds. Klaus Groschner, Wolfgang F. Graier & Christoph Romanin by Springer [Link]
Waldeck-Weiermair, M., Jean-Quartier, C., Rost, R., Khan, M.J., Vishnu, N., Bondarenko, A.I., Imamura, H., Malli, R. & Graier, W.F. The leucine zipper EF hand-containing transmembrane protein 1 (LETM1) and uncoupling proteins- 2 and 3 (UCP2/3) contribute to two distinct mitochondrial Ca2+ uptake pathways. J. Biol. Chem. 286: 28444-28455, 2011 [Fulltext] [Pubmed]
Bondarenko, A.I., Malli, R. & Graier, W.F. The GPR55 agonist lysophosphatidylinositol directly activates intermediate conductance Ca2+ activated K+ channels. Pflügers Arch. - Eur. J. Physiol. 462: 245–255, 2011 [Fulltext] [Pubmed]
Bondarenko, A.I., Malli, R. & Graier, W.F. The GPR55 agonist lysophosphatidylinositol acts as an intracellular messenger and bidirectionally modulates Ca2+-activated large-conductance K+ channels in endothelial cells. Pflügers Arch. - Eur. J. Physiol. 461: 177-189, 2011 [Fulltext] [Pubmed]
Aflaki, E., Radovic, B., Chandak, P.G., Kolb, D., Eisenberg, T., Ring, J., Fertschai, I., Uellen, A., Wolinski, H., Kohlwein, S.D., Zechner, R., Levak-Frank, S., Sattler, W., Graier, W.F., Malli, R., Madeo, F. & Kratky D. Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. J.Biol. Chem. 286: 7418-7428, 2011 [Fulltext] [Pubmed]
2010
Waldeck-Weiermair, M., Duan, X., Naghdi, S., Khan, M.J., Trenker, M., Malli, R. & Graier, W.F. Uncoupling protein 3 adjusts mitochondrial Ca2+ uptake to high and low Ca2+ signals. Cell Calcium 48: 288-301, 2010 [free Fulltext] [Pubmed] doi:10.1016/j.ceca.2010.10.004
Riederer , M., Ojala; P.J., Hrzenjak, A., Graier, W.F., Malli, R., Tritscher, M., Hermansson, M., Watzer, B., Schweer, H., Desoye, G., Heinemann, A. & Frank, S. Acyl chain-dependent effect of lysophosphatidylcholine on endothelial prostacyclin production. J. Lipid. Res. 51: 2957-2966, 2010 [Fulltext] [Pubmed]
Naghdi, S., Waldeck-Weiermair, M., Fertschai, I., Poteser, M., Graier, W.F. & Malli, R. Mitochondrial Ca2+ uptake and not mitochondrial motility is required for STIM1/Orai1-dependent store-operated Ca2+ entry. J. Cell Sci. 123: 2553-2564, 2010 [Fulltext] [PubMed]
Waldeck-Weiermair, M., Malli, R., Naghdi, S.,Trenker, M., Kahn, M.J. & Graier, W.F. The contribution of UCP2 and UCP3 to mitochondrial Ca2+ uptake is differentially determined by the source of supplied Ca2+. Cell Calcium 47: 433-440, 2010 (doi:10.1016/j.ceca.2010.03.004) [Fulltext] [PubMed]
Bondarenko, A., Waldeck-Weiermair, M., Naghdi, S., Poteser, M., Malli, R. & Graier, W.F. G-protein coupled receptor 55-dependent and -independent ion signaling in response to lysophosphatidylinositol in endothelial cells. Br. J. Pharmacol. 161: 308-320, 2010 [free Fulltext] [PubMed] -> download PDF
Schmidt, K. Martens-Lobenhoffer, J., Meinitzer, A., Graier, W.F., Torres, C.M., Venema, R.C. & Mayer, B. Activation of endothelial nitric oxide synthase by the pro-apoptotic drug embelin: striking discripancy between nitric oxide-mediated cyclic GMP accumulation and L-citrulline formation. Nitric Oxide 22: 281-289, 2010 [Fulltext] [PubMed]
Bentley, M., Nycz, D., Joglekar, A., Fertschai, I., Malli, R., Graier, W.F. & Hay, J.C. Vesicular calcium regulates coat retention, fusogenicity and size of pre-golgi intermediates. Molecular Biology of the Cell 21: 1033-1046, 2010 [Fulltext] [PubMed]
Malli, R. & Graier, W.F. Mitochondrial Ca2+ Channels: Great Unknowns with Important Functions. FEBS Lett. 584: 1942-1947, 2010 [Fulltext] [PubMed]
Bernhart, E., Kollroser, M., Rechberger, G., Reicher, H., Heinemann, A., Schratl, P., Hallstroem, S., Wintersperger, A., Nusshold, C.. DeVane T., Zorn-Pauly, K., Malli, R., Graier, W., Malle, E., and Sattler, W. Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture. Proteomics 10: 141-158, 2010 [Fulltext] [PubMed]
2009
Graier, W.F., Malli, R. and Kostner, G.M. Mitochondrial protein phosphorylation: Instigator or target of lipotoxicity? Trends in Endocrinology and Metabolism 20: 186-193, 2009 (Review) [Fulltext] [PubMed]
2008
Trenker, M., Fertschai, I., Malli, R. and Graier, W.F. UCP2/3 – Likely to be fundamental for mitochondrial Ca2+ uniport. Nat. Cell. Biol. 10: 1237-1240, 2008 (Correspondence; doi:10.1038/ncb1108-1237) [Fulltext] [PubMed]
Graier, W.F. and Hecker, M. Endothelial H2O2: a bad guy turing good? Arteriosler. Thromb. Vasc. Biol. 28: 1696-1698, 2008 (doi:10.1161/ATVBAHA.108.173963; Editorial) [Fulltext] [PubMed]
Malli, R., Shamim Naghdi, S., Romanin, C. and Graier, W.F. Cytosolic Ca2+ prevents the subplasmalemmal clustering of STIM1: an intrinsic mechanism to avoid Ca2+ overload. J. Cell. Sci. 121: 3133-3139, 2008 (doi:10.1242/jcs.034496) [Fulltext] [PubMed]
Jousset, H., Malli, R., Girardin, N.C., Graier, W.F., Demaurex, N. and M. Frieden, M. Evidence for a receptor-activated Ca2+ entry pathway independent from Ca2+ store depletion in endothelial cells. Cell Calcium 43: 83-94, 2008 [Fulltext] [PubMed]
Graier, W.F., Trenker, M. and Malli, R. Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3? Cell Calcium 44: 36-50, 2008 (doi: 10.1016/j.ceca.2008.01.001; Review) [Fulltext] [PubMed]
Waldeck-Weiermair, M., Zoratti, C., Osibow, K., Balenga, N., Goessnitzer, E., Waldhoer, M., Malli, R. and Graier, W.F. Integrin-clustering enables endocannabinoid-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor triggered repression. J. Cell. Sci. 121: 1704-1717, 2008 (doi: 10.1242/jcs.020958) [Fulltext] [PubMed]
Schweiger, M., Schoiswohl, G., Lass, A., Radner, F.P.W., Haemmerle, G., Malli, R., Graier, W.F., Cornaciu, I., Oberer, M., Salvayre, R., Fischer, J., Zechner, R. and Zimmermann, R. The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding. J. Biol. Chem. 283: 17211-17220, 2008 (doi:10.1074/jbc.M710566200) [Fulltext] [PubMed]
2007
Malli, R., Frieden, M., Hunkova, M., Trenker, M. and Graier, W.F.Ca2+ refilling of the endoplasmic reticulum is largely preserved albeit reduced Ca2+ entry in endothelial cells. Cell Calcium 41: 63-76, 2007 [Fulltext] [PubMed]
Trenker, M., Malli, R., Fertschai, I., Levak-Frank, S., and Graier, W.F. Uncoupling-proteins 2 and 3 are elementary for mitochondrial Ca2+ uniport. Nat. Cell. Biol. 9: 445-452, 2007, doi:10.1038/ncb1556 [Fulltext] [PubMed]
Graier, W.F., Frieden, M. and Malli, R. Mitochondria and Ca2+ signaling: old guests, new functions. Pflügers Archiv - European Journal of Physiology 455: 375-396, 2007 (Review) [Fulltext] [PubMed]
Wiesenberger, G., Steinleitner, K., Malli, R., Graier, W.F., Schweyen, R.J. and Stadler, J.A. Mg2+ deprivation elicits rapid Ca2+ uptake and activates Ca2+/calcineurin signaling in Saccharomyces cerevisiae. Eucarytotic Cell 6: 592-599, 2007, doi:10.1128/EC.00382-06 [Fulltext] [PubMed]
2006
Osibow, K., Frank, S., Malli, R., Zechner, R. and Graier, W.F. Mitochondria maintain maturation and secretion of lipoprotein lipase in the endoplasmic reticulum. Biochem. J. 396: 173-182, 2006. [Fulltext] [PubMed]
Osibow, K., Malli, R., Kostner, G.M. and Graier, W.F. A new type of non-Ca2+ -buffering apo(a)-based fluorescent indicator for intraluminal Ca2+ in the endoplasmic reticulum. J. Biol. Chem. 281: 5017-5025, 2006 [Fulltext] [PubMed]
2005
Kipmen-Korgun, D., Osibow, K., Zoratti, C., Schraml, E., Greilberger, J., Kostner, Juergens, G. and Graier, W.F. T-cadherin mediates low-density lipoprotein-initiated cell proliferation via the Ca2+-tyrosine kinase-Erk1/2 pathway. J. Cardiovasc. Pharmacol. 45: 418-430, 2005 [Fulltext] [PubMed]
Malli, R, Frieden, M., Trenker, M. and Graier, W.F. The role of mitochondria for Ca2+ refilling of the ER. J. Biol. Chem. 280: 12114-12122, 2005 [Fulltext] [PubMed]
Knot, H.J., Laher, I., Sobie, E.A., Guatimosim, S., Gomez-Viquez, L., Hartmann, H., Song, L.-S., Lederer, W.J.,Graier, W.F., Malli, R., Frieden, M., and Petersen, O.H. Twenty years of calcium imaging: cell physiology to dye for. Molec. Interventions 5: 112-127, 2005 (Review) [Fulltext] [PubMed]
2004
Bilban, M., Ghaffari-Tabrizi, N., Hintermann, E., Bauer , S., Molzer, S., Zoratti, C., Malli, R., Sharabi, A., Hiden, U., Graier, W.F., Knöfler, M., Andreae, F., Wagner, O., Quaranta1, V. and Desoye, G. Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiologic invasion inhibitor of primary human trophoblasts. J Cell Sci 117:1319-1328, 2004
Graziani, A., Bricko, V. Wolfgang F. Graier, W.F. and Klaus Groschner. Cholesterol-and caveolin-rich membrane domains are essential for phospholipase A2-dependent EDHF formation. Cardiovasc Res. 64: 234-242, 2004
Paltauf-Doburzynska, J., Malli,R. and Graier, W.F. Hyperglycemic conditions affect shape and Ca2+ homeostasis of mitochondria in endothelial cells. J. Cardiovasc. Pharmacol. 44: 424-437, 2004
Marsche, G.,, Heller , R., Nuszkowsi , A., Fauler , G., Kovacevic, A., Graier, W.F., Sattler , W. and Malle, E. 2-Chlorohexadecanal, derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis. Arteriosler. Thromb. Vasc. Biol. 24:2302-2306, 2004
2003
Schaeffer, G., Levak-Frank, S., Spitaler, M.M., Fleischhacker, E., Esenabhalu, V.E., Wagner, A.H., Hecker, M. and Graier, W.F. Intercellular signaling within vascular cells under high d-glucose involves free radical-triggered tyrosine kinase activation. Diabetologia 46: 773-783, 2003
Malli, R., Frieden, M., K. Osibow, K. and W.F. Graier, W.F. Mitochondria efficiently buffer subplasmalemmal Ca2+ elevation during agonist stimulation. J. Biol. Chem. 278: 10807-10815, 2003
Esenabhalu, V.E., Schaeffer, G. and Graier, W.F. Free fatty acid overload attenuates Ca2+ signaling and no production in endothelial cells. Antioxidants & Redox Signaling 5: 147-153, 2003
Artwohl, M., Graier, W.F., Roden, M., Bischof, M.,Freudenthaler, Waldhäusl, W.,A. and Baumgartner-Parzer, S.M. Diabetic low-density lipoprotein triggers apoptosis in vascular endothelial cells. Diabetes 52: 1240-1247, 2003
Zoratti, C., Kipmen-Korgun, D., Osibow, K., Malli, R. and Graier, W.F. Anandamide initiates Ca2+ signaling via CB2-receptor linked to phospholipase C in calf pulmonary endothelial cells. Br. J. Pharmacol. 140: 1351-1362, 2003
Malli, R., Frieden, M., Osibow, K., Mayer, M., Demaurex, N. and Graier, W.F. Sustained Ca2+ transfer across mitochondria is essential for mitochondrial Ca2+ buffering, store-operated Ca2+ entry, and Ca2+ store refilling. J. Biol. Chem. 278: 44769-44779, 2003
2002
Bochkov, V.N., Mechtcheriakova, D., Lucerna, M., Huber, J., Malli, R., Graier, W.F., Binder, B.R and Leitinger, N. Oxidized 1-palmitoyl-2-arachidonolyl-sn-glycero-3-phosphorylcholine (OxPAPC) stimulates expression of tissue factor in human endothelial cells through activation of erk/erg-1 and Ca2+/NFAT. Blood 99: 199-206, 2002
Esenabhalu, V.E., Cerimagic, M., Malli, R., Osibow, K., Levak-Frank, S., Frieden, M., Sattler, W., Kostner, G.M. Zechner, R. and Graier, W.F. Tissue specific expression of human lipoprotein lipase in the vacular system affects vascular reactivity in transgenic mice. Br. J. Pharmacol. 135: 143-154, 2002
Frieden, M., Malli, R., Samardzija, M., Demaurex, N. and Graier, W.F. Subplasmalemmal endoplasmic reticulum controls KCa channel activity upon stimulation with moderate histamine concentration in a human umbilical vein endothelial cell line. J. Physiol. 544: 73-84, 2002 (issue’s cover image).
Thyagarajan, B., Malli, R., Schmidt, K., Graier, W.F. and Groschner, K. Evidence for a pivotal role of mitochondria in regulation of capacitive Ca2+entry by nitric oxide. Br. J. Pharmacol. 137: 821-830, 2002
Spitaler, M.M. and Graier, W.F. Vascular targets of redox signalling in diabetes mellitus. Diabetologia 45: 476-494, 2002
Tiran, A., Gruber, H.J., Graier, W.F., Wagner, A.H., Wilders-Truschnig, M. and Tiran, B. Aspirin inhibits Chlamydia pneumoniae-induced NF-kB Activation, cytokine expression and Bacterial development in human endothelial cells. Arteriosler. Thromb. Vasc. Biol. 22:1075-1080, 2002
Spitaler, M., Hammer, A., Malli, R. and Graier, W.F. Functional analysis of histamine receptor subtypes involved in endothelial-mediated relaxation of the human uterine artery. Clin. Exp. Pharmacol. Physiol. 29: 211-216, 2002
2001
Schulter, V., Koolwijk, P., Peters, E., Frank, S., Hrzenjak, A., Graier, W.F., van Hingsbergh, V.W.M. and Kostner, G.M. The impact of apo(a) on in vitro angiogenesis. Arterioscler. Thromb. Vasc. Biol. 21:433-438, 2001
Zimmermann, R., Panzenböck, U., Wintersberger, Levak-Frank, S., Graier, W.F., Glatter, O., Fritz, G., Kostner, G.M. and Zechner, R. Lipoprotein lipase mediates the uptake of glycated low density lipoprotein in fibroblasts, endothelial cells, and macrophages. Diabetes 50: 1643-1653, 2001
Ugdyzhekova, D.S., Bernatskaya, N.A., Stefano, J.B., Graier, V.F., Tam, S.W., Mekhoulam, R. Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of cb1 and cb2 receptors. Bull. Exp. Biol. Med. 131:251-253, 2001
Bowles, D.K., Graier, W.F. and Sturek, M. Hydrogene peroxide activates Na+ dependent Ca2+ influx in coronary endothelial cells. Biochem. Biophys. Res. Commun. 287: 1134-1139, 2001
2000
Fleischhacker, E., Esenabhalu, V.E., Holzmann, S., Skrabal, F., Koidl, B., Kostner, G.M. and Graier, W.F. In human hypercholesterolemia increased reactivity of smooth muscle cells is due to altered subcellular Ca2+ distribution. Atherosclerosis 149: 33-42, 2000
Paltauf-Doburzynska, J., Frieden, M., Spitaler, M. and Graier, W.F.Histamine-induced Ca2+ oscillations in a human endothelial cell line depend on transmembrane ion flux, ryanodine receptor and SERCA. J. Physiol. Lond. 524: 701-713, 2000
Frieden, M. and Graier, W.F. Subplasmalemmal ryanodine-sensitive Ca2+ release contributes to KCa channel activation in a human umbilical vein endothelial cell line. J. Physiol. Lond. 524: 715-724, 2000
Prates, S., Hörl, G., Graier, W.F., Sattler, W., Zechner, R. and Steyrer, E. Intracellular distribution and mobilization of unesterified cholesterol in adipocytes. J. Cell. Sci. 113: 2977-2889, 2000
Lintschinger, B., Balzer-Geldsetzer, M., Baskaran, T., Graier, W.F., Romanin, C. Zhu, M.X. and Groschner, K. Coassembly of Trp1 and Trp3 channels generates diacylglycerol and Ca2+ sensitive cation channels. J. Biol Chem. 275:27799-27805, 2000
1999
Posch, K., Schmidt, K. and Graier, W.F. Shear stress selectively stimulates uptake of L-arginine in endothelial cells - A mechanism essential for shearstress-mediated formation of nitric oxide. Life Sci. 64: 663-670, 1999
Schaeffer, G., Wascher, T.C., Kostner, G.M. and Graier, W.F. Alterations in platelet Ca2+ signaling in diabetic patients is due to increased formation of superoxide anions and reduced nitric oxide production. Diabetologia 42: 167-176, 1999
Fleischhacker, E., Esenabhalu, V.E., Spitaler, M., Holzmann, S., Skrabal, F., Koidl, B., Kostner, G.M. and Graier, W.F. Human diabetes mellitus is associated with hyperreactivity of vascular smooth muscle cells due to altered subcellular Ca2+ distribution. Diabetes 48:1323-1330, 1999
Mombouli, J.V., Holzmann, S., Kostner, G.M. and Graier, W.F. Potentiation of endothelial Ca2+ signaling by 11,12-epoxyeicosatrienoic acid. J. Cardiovasc. Pharmacol. 33: 779-784, 1999
Mombouli, J.V., Schaeffer, G., Holzmann, S.,Kostner, G.M. and Graier, W.F. Anandamide-induced mobilization of cytosolic Ca2+ in endothelial cells. Br. J. Pharmacol. 126: 1593-1600, 1999
Posch, K., Wascher, T.C., Baumgartner-Parzer, S., Kostner, G.M. and Graier, W.F. Glycated low-density lipoprotein attenuates shear stress-induced nitric oxide synthesis by inhibition of shear stress activated L-arginine uptake in endothelial cells. Diabetes 48:1331-1337, 1999
Paltauf-Doburzynska, J., Frieden, M. and Graier, W.F. Mechanisms of Ca2+ store depletion in single endothelial cells in a Ca2+-free environment. Cell Calcium 25: 345-353, 1999
Graier, W.F., Posch, K., Fleischhacker, E., Wascher, T.C. and Kostner, G.M.Increased superoxide anion formation in endothelial cells during hyperglycemia - An adaptive response or initial step of vascular dysfunction? Diab. Res. Clin. Pract. 45: 153-160, 1999
1998
Graier, W.F., Paltauf-Doburzynska, J., Hill, B., Fleischhacker, E., Hoebel, B.G., Kostner, G.M. and Sturek, S. Submaximal stimulation of porcine endothelial cells causes focal Ca2+ elevation beneath the cell membrane. J. Physiol. Lond. 506: 109-125, 1998
Hoebel, B.G. and Graier, W.F. 11,12-Epoxyeicosatrienoic acid stimulates tyrosine kinase activity in porcine aortic endothelial cells. Eur. J. Pharmacol. 346: 115-117, 1998
Graier, W.F., Hoebel, B.G., Paltauf-Doburzynska, J. and Kostner, G.M. Effects of Superoxide Anions on Endothelial Ca2+ Signaling Pathways. Arteriosler. Thromb. Vasc. Biol. 18: 1470-1479, 1998
Paltauf-Doburzynska, J., Posch, K., Paltauf, G. and Graier, W.F. Stealth ryanodine-sensitive Ca2+ release contributes to activity of capacitative Ca2+ entry and nitric oxide synthase in human and bovine endothelial cells. J. Physiol. Lond. 513: 369-379, 1998
Hoebel, B.G., Steyrer, E. and Graier, W.F. Origin and function of epoxyeicosa-trienoic acids in vascular endothelial cells - More than just endothelium-derived hyperpolarizing factor? Clin. Exp. Pharmacol. Physiol. 25: 826-830, 1998
1997
Paltauf-Doburyzenska, J. and Graier, W.F. Temperature-dependence of agonist-stimulated Ca2+ signaling in cultured endothelial ccells. Cell Calcium 21: 43-51, 1997
Graier, W.F., Simecek, S., Hoebel, B.G., Wascher, T.C., Dittrich, P and Kostner, G. Antioxidants prevent high D-glucose-enhanced endothelial Ca2+/cGMP response by scavanging superoxide anions. Eur. J. Pharmacol. 322: 113-121 1997
Wascher, T.C., Posch, K., Wallner, S., Hermetter, A., Kostner, G.M. and Graier, W.F. Vascular effects of L-arginine: anything beyond a substrate for the NO-synthase? Biochem. Biophys. Res. Commun. 234: 35-38, 1997
Wascher, T.C., Graier, W.F., Dittrich, P., Hussain, M.A., Bahadori, B., Habersack-Wallner, S.and Toplak, H. Effects of low-dose L-arginine on insulin-mediated vasodilation and insulin sensitivity. Eur. J. Clin. Invest. 26: 707-712, 1997
Hoebel, B.G., Kostner, G.M and Graier, W.F. Microsomal cytochrome P450 mono-oxygenase is activated by Ca2+ store depletion and contributes to Ca2+ entry in porcine aortic endothelial cells. Br. J. Pharmacol. 121: 1579-1588, 1997
Graier, W.F., Posch, K., Wascher, T.C., Kukovetz, W.R. and Kostner, G.M. Role of superoxide anions in change of endothelial vasoactive response during acute hyperglycemia. Horm. Met. Res. 29: 622-629, 1997
Graier, W.F. and Kostner, G.M. Glycated LDL and atherosclerosis: The missing link between diabetes mellitus and hypercholesterolemia? Eur. J. Clin. Invest. 27: 457-459, 1997 (Editorial)
1996
He, G.-W., Yang, C.-Q., Graier, W.F. and Yang, J.-A.. Hyperkalemia alters EDHF-mediated hyperpolarization and relaxation in coronary arteries. Am. J. Physiol. 271: H760-H767, 1996
Wascher, T.C., Bachernegg, M., Kickenweiz, A., Stark, G., Stark, U., Toplak, H. and Graier. Involvement of the L-arginine-nitric oxide pathway in hyperglycemia-induced coronary artery dysfunction of ioslated guinea pig hearts. E. J. Clin. Invest. 26: 707-712, 1996
Graier, W.F., Simecek, S., Kukovetz, W.R. and Kostner, G.M. High D-glucose-induced changes in endothelial Ca2+/EDRF signaling is due to generation of superoxide anions. Diabetes 45: 1386-1395, 1996
Graier, W.F., Holzmann, S., Hoebel, B.G., Kukovetz, W.R. and Kostner, G.M. Mechanism of L-NG-nitroarginine/indomethacin-resitant relaxation in bovine and porcine coronary arteries. Br. J. Pharmacol. 119: 1177-1186, 1996
1995
Graier, W.F., Simecek, S., and Sturek, M. Cytochrome P450 mono-oxygenase-regulated signaling of Ca2+ entry in human and bovine endothelial cells. J. Physiol. Lond. 482: 259-274, 1995
Wascher, T.C., Bachernegg, M., Kickenweiz, A., Stark, G., Toplak, H., and Graier, W.F., Krejs, G.J. Elevation of D-glucose impairs coronary artery autoregulation under slight reduction of coronary flow. E. J. Clin. Invest. 25: 590-594, 1995
Graier, W.F., Grubenthal, I., Peter Dittrich, P., Thomas C. Wascher, T.C., Kostner, G.M. Intracellular mechanism of high D-glucose-induced modulation of vascular cell proliferation. Eur. J. Pharmacol. 294: 221-229, 1995
Brunner, F., Stessel, H., and Graier, W.F. The effects of intracellular Ca2+ concentration and hyopxia on basal endothelin-1 secretion by cultured bovine aortic endothelial cells. Agents Actions (Suppl.) 45:269-273, 1995
Toplak, H., Graier, W.F., Dittrich, P., Wiesmann, U.N. and Wascher, T.C. Insulin resistance and membrane abnormalties. Lancet 345: 995, 1995 (Letter)
1994
Holzmann, S., Kukovetz, W.R., Windischhofer, W., Paschke, E., and Graier, W.F. Pharmacological differentiation between EDRF- and EDHF-mediated relaxation of coronary arteries. J. Cardiovasc. Pharmacol. 23: 747-756, 1994
Wascher, T.C., Toplak, H., Krejs, G.J., Simecek, S., Kukovetz, W.R., and Graier, W.F. Intracellular mechanisms involved in D-glucose-mediated amplification of agonist-induced Ca2+ response and EDRF formation in vascular endothelial cells. Diabetes 43: 984-991, 1994
Graier, W.F., Simecek, S., Bowles, D.K. and Sturek, M. Heterogeneity of caffeine and bradykinin-sensitive stores in vascular endothelial cells.Biochem. J. 300: 637-641, 1994
Groschner, K., Graier, W.F. and Kukovetz, W.R. Histamine induces K+, Ca2+ and Cl- currents in human vascular endothelial cells - Role of ionic currents in stimulation of nitric oxide biosynthesis. Circ. Res. 75: 304-314, 1994
Graier, W.F., Myers, P.R., Rubin, L.J., Adams, H.R. and Parker, J.L. Escherichia coli endotoxin inhibits agonist-mediated cytosolic calcium mobilization and nitric oxide biosynthesis in cultured endothelial cells. Circ. Res. 75: 659-668, 1994
Brunner, F., Stessel, H., Simecek, S and Graier, W.F., and Kukovetz, W.R. Effect of intracellular Ca2+ concentration on endothelin-1 secretion. Febs Lett. 350: 33-36, 1994
Wascher, T.C., Toplak, H., Bahadori, B., Graier, W.F. and Krejs, G.J. Time course of endothelial dysfunction in diabetes mellitus. Circulation 90: 1109, 1994 (Letter)
Graier, W.F., Sturek, M., and Kukovetz, W.R. Ca2+ regulation and endothelial vascular function. Endothelium 1: 223-236, 1994.
1993
Graier, W.F., Groschner, K., and Kukovetz, W.R. cAMP enhances agonist-induced Ca2+ entry into endothlial cells by activation of potassium channels and membrane hyperpolarization. Biochem. J. 291:263-267, 1993
Graier, W.F., Wascher, T.C., Lackner, L., Toplak, H., Krejs, G.J., and Kukovetz, W.R. Prolonged exposure to elevated glucose concentrations modulates vascular endothelial cell vasodilatatory response. Diabetes 42: 1497-1505, 1993
1992
Graier, W.F., Schmidt, K., and Kukovetz, W.R. Is the bradykinin-induced Ca2+ influx and the formation of endothelium derived relaxing factor mediated by a G protein? European J. Pharmacol. - Molecular Pharmacology Section, 225: 43-49, 1992
Schmidt, K., Klatt, P., Graier, W.F., Kostner, G.M., and Kukovetz, W.R. High-density lipoprotein antagonizes the inhibitory effects of oxidized low-density lipoprotein and lysolecithin on soluble guanylyl cyclase. Biochem. Biophys. Res. Commun. 182: 302-308, 1992
Groschner, K., Graier, W.F., and Kukovetz, W.R. Activation of a small-conductance Ca2+-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells. Biochim. Biophys. Acta 1137: 162-170, 1992
Graier, W.F., Groschner, K., Schmidt, K., and Kukovetz, W.R. SK&F 96365 inhibits histamine-induced formation of endothelium-derived relaxing factor in human endothelial cells. Biochem. Biophys. Res. Commun. 186: 1539-1545, 1992
Graier, W.F., Groschner, K., Schmidt, K., and Kukovetz, W.R. Increases in endothelial cAMP levels amplify agonist-induced formation of endothelium-derived relaxing factor (EDRF). Biochem. J. 288: 345-349, 1992
Kukovetz, W.R., Graier, W.F., and Groschner, K. Contribution of agonist-induced hyperpolarization to Ca2+ influx and formation of EDRF in vascular endothelial cells. Jap. J. Pharmacol. 58 (Suppl.2): 213P-219P, 1992
1991
Schmidt, K., Graier, W.F., Kostner, G.M., Mayer, B., Böhme, E., and Kukovetz, W.R. Oxidized low-density lipoprotein antagonizes the stimulation of soluble guanylate cyclase by endothelium-derived relaxing factor. Cell. Signal. 3: 361-367, 1991
Graier, W.F., Schmidt, K., and Kukovetz, W.R. Bradykinin-induced Ca2+-influx into cultured endothelial cells is not regulated by inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate. Second Messengers and Phosphoproteins 13: 187-197, 1991
Graier, W.F., Schmidt, K., and Kukovetz, W.R. Activation of G-protein evokes Ca2+ -influx in endothelial cells without correlation to the formation of inositolphosphates. J. Cardiovasc. Pharmacol. 17 (Suppl.3) S71-S78, 1991
Schmidt, K., Graier, W.F., Kostner, G.M., Mayer, B., Böhme, E., and Kukovetz, W.R. Stimulation of soluble guanylate cyclase by EDRF is antagonized by oxidized low-density lipoprotein. J Cardiovasc Pharmacol 17 (Suppl.3) S83-S86, 1991
1990
Graier, W.F., Schmidt, K., and Kukovetz, W.R. Effect of sodium fluoride on cytosolic free Ca2+-concentration and cGMP-formation in endothelial cells. Cell. Signal. 2: 369-375, 1990
Schmidt, K., Graier, W.F., Kostner, G.M., Mayer, B., and Kukovetz, W.R. Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein. Biochem. Biophys. Res. Commun. 172: 614-619, 1990
Technical Notes:
Graier, W.F. and Malli, R. Novel live-cell dual excitation/dual emission imaging system for the simultaneous visualization of cytosolic Ca2+ signaltransduction processes and mitochondrial dynamics. International Labmate August 70-71, 2007 [PDF]
Proceedings:
Paltauf-Dobuzynska, J., Kohlwein, S.D. and Graier, W.F. Digital imaging of diabetic endothelial cells. Progress in biomedical optics and imaging 4260: 1-6, 2001
Graier, W.F. and Wascher, T.C. Zelluläre Grundlagen der Gefäßkomplikationen im Diabetes mellitus. Journal für Kardiologie 7: 9-13, 2000
Rubin, L.J., Adams, H.R., Myers, P.R., Graier, W.F. and Parker, J.L. Inhibition of endothelial cell NOS in sepsis and shock. Proceedings of the Third International Shock Congress, Hamamatsu, Japan. In: Excerpta Medica International Congress Series 1102. Elsevier Science, The Netherlands, 1996, pg. 25-36
Graier, W.F. Bedeutung und Rolle des endothelialen Relaxationsfaktors. ÖAZ 46 Jg (23): 457-459, 1992
Schmidt, K., und Graier, W.F. Stereoselektivität bei bioaktiven Substanzen - ein aktuelles Problemgebiet in Chemie und Biologie. ÖAZ 43 Jg. (39): 745-746, 1989
Book chapters:
Mombouli, J.V., Zeldin, D., Scott-Burden, T., Holzmann, S., Kostner, G.M. and Graier, W.F. Functional dualism of the endothelium-derived hyperpolarizing factors epoxyeicosatrienoic acids: Potentiation of Ca2+ signaling in endothelial and vascular smooth muscle cells. In: Endothelium-dependent Hyperpolarizations, 1999. Ed Paul M. Vanhoutte, Harwood Press, London, pg. 77-84
Graier, W.F., Hoebel, B.G., Frank, S. and Kostner, G.M. Intracellular action of epoxyeicosatrienoic acids in endothelial cells In: Endothelium-dependent Hyperpolarizations, 1999. Ed Paul M. Vanhoutte, Harwood Press, London, pg. 69-76
Graier, W.F., Simecek, S., Höbel, B.G., Kukovetz, W.R., and Kostner, G.M. Cytochrome P450 mono-oxygenase regulates endothelial Ca2+ entry and formation of endothelium-derived factors. In. Endothelium-derived Hyperpolarizing Factor, 1996, EDHF. Ed Paul M. Vanhoutte, Harwood Press, London, pg. 119-125
Graier, W.F., Schmidt, K., and Kukovetz, W.R. Mechanism of bradykinin induced Ca2+ influx into vascular endothelial cells. in: Recent Adevences In Cellular And Molecular Biology. edit. Wegmann & Wegmann, Peeters Press, Vol. 4: 199-203, 1992
Schmidt, K., Graier, W.F., and Kukovetz, W.R. EDRF-Formation increases cGMP-levels in cultured endothelial cells. in: Advances of Cyclic Nucleotide Research and Protein Phosphorylation (The Biology and Medicine of Signal Transduction). edit. by Yasutomi Nishizuka, 455-460, 1990
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