Homepage of Thomas Pfeifer



Group members Sanja Levak-Frank Jay Patankar Sascha Obrowsky Collaborators Dagmar Kratky Gert M. Kostner PhD Program Molecular Medicine	Thomas Pfeifer, MSc PhD student Calling card	Institute of Molecular Biology and Biochemistry Center of Molecular Medicine Medical University of Graz Harrachgasse 21/III 8010 Graz, Austria Phone: +43 (316) 380 1940 Fax: +43 (316) 380 9615 Curriculum Vitae Project description



Research area Functional characterization of new LXR-target proteins in cholesterol absorption in the small intestine using in vitro and in vivo models Investigation of LXR mediated effects on cholesterol absorption in vivo and in vitro Characterization of oxysterol derived LXR agonists Methods: Cloning and RT-PCR, Western Blot, Cell Culture, in vivo experiments in mouse (gavaging,bleeding,dissecting), lipid analysis (thin layer chromatography (TLC), cholesterol and triglyceride estimation), working with radioactive substances, Publications Synthetic LXR agonist attenuates plaque formation in apoE-deficient mice without inducing liver steatosis and hypertriglyceridemia. J Lipid Res. 2008 Sep 23, Kratzer A, Buchebner M, Pfeifer T, Becker TM, Uray G, Miyazaki M, Miyazaki-Anzai S, Ebner B, Chandak PG, Kadam RS, Calayir E, Rathke N, Ahammer H, Radovic B, Trauner M, Hoefler G, Kompella UB, Fauler G, Levi M, Levak-Frank S, Kostner GM, Kratky D.