Publications of Dr. Sanja Levak-Frank
Trenker M, Malli R, Fertschai I, Levak-Frank S, Graier WF. (2007) Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport.
Nat. Cell. Biol. Apr;9(4):445-52. Epub 2007 Mar 11.
Sovic A, Panzenboeck U, Wintersperger A, Kratzer I, Hammer A, Levak-Frank S, Frank S, Rader DJ, Malle E, Sattler W. (2005) Regulated expression of endothelial lipase by porcine brain capillary endothelial cells constituting the blood-brain barrier. J. Neurochem., 94:109-119. [pdf]
Schaeffer G, Levak-Frank S, Spitaler MM, Fleischhacker E, Esenabhalu VE, Wagner AH, Hecker M, Graier WF. (2003) Intercellular signalling within vascular cells under high D-glucose involves free radical-triggered tyrosine kinase activation. Diabetologia, 46(6):773-783. [pdf]
Wadsack C, Hammer A, Levak-Frank S, Desoye G, Kozarsky KF, Hirschmugl B, Sattler W, Malle E.(2003) Selective cholesteryl ester uptake from high density lipoprotein by human first trimester and term villous trophoblast cells. Placenta, 24(2-3):131-143. [Abstract]
Wadsack C, Hirschmugl B, Hammer A, Levak-Frank S, Kozarsky KF, Sattler W, Malle E. (2003) Scavenger receptor class B, type I on non-malignant and malignant human epithelial cells mediates cholesteryl ester-uptake from high density lipoproteins. Int. J. Biochem. Cell Biol., 44:2089-2099. [pdf]
Strauss JG, Hayn M, Zechner R, Levak-Frank S, Frank S. (2003) Fatty acids liberated from high-density lipoprotein phospholipids by endothelial-derived lipase are incorporated into lipids in HepG2 cells. Biochem. J., 371(Pt 3):981-988. [pdf]
Wadsack C, Hrzenjak A, Hammer A, Hirschmugl B, Levak-Frank S, Desoye G, Sattler W, Malle E. (2003) Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins. Eur. J. Biochem., 270(3):451-462. [pdf]
Panzenboeck U, Balazs Z, Sovic A, Hrzenjak A, Levak-Frank S, Wintersperger A, Malle E, Sattler W. (2002) ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. J. Biol. Chem., 277(45):42781-42789. [pdf]
Strauss JG, Zimmermann R, Hrzenjak A, Zhou Y, Kratky D, Levak-Frank S, Kostner GM, Zechner R, Frank S.(2002) Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity. Biochem J. , 368(Pt 1):69-79. [pdf]
Esenabhalu VE, Cerimagic M, Malli R, Osibow K, Levak-Frank S, Frieden M, Sattler W, Kostner GM, Zechner R, Graier WF. (2002) Tissue-specific expression of human lipoprotein lipase in the vascular system affects vascular reactivity in transgenic mice. Br. J. Pharmacol., 135(1):143-154. [Abstract]
Voshol P.J., Jong M.C., Dahlmans V., Kratky D., Levak-Frank S., Zechner R., Romijn J.A. and Havekes L. (2001) In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. Diabetes, 50:2585-2590. [pdf]
Zimmermann R, Panzenbock U, Wintersperger A, Levak-Frank S, Graier W, Glatter O, Fritz G, Kostner GM, Zechner R. (2001) Lipoprotein lipase mediates the uptake of glycated LDL in fibroblasts, endothelial cells, and macrophages. Diabetes, 50(7):1643-1653. [pdf]
Marsche G, Levak-Frank S, Quehenberger O, Heller R, Sattler W, Malle E. (2001)Identification of the human analog of SR-BI and LOX-1 as receptors for hypochlorite-modified high density lipoprotein on human umbilical venous endothelial cells. FASEB J., 15(6):1095-1097. [pdf]
Goti D, Hrzenjak A, Levak-Frank S, Frank S, van der Westhuyzen DR, Malle E, Sattler W. (2001)Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E. J. Neurochem., 76(2):498-508. [pdf]
Zechner R., Strauss J., Frank S., Hofmann W., Kratky D., Hiden M. and Levak-Frank S. (2000) The role of lipoprotein lipase in adipose tissue development and metabolism. Int. J. Obesity, 24 Suppl 4:S53-S56.
Wang X, Greilberger J, Levak-Frank S, Zimmermann R, Zechner R, Jurgens G. (1999) Endogenously produced lipoprotein lipase enhances the binding and cell association of native, mildly oxidized and moderately oxidized low-density lipoprotein in mouse peritoneal macrophages. Biochem J., 343 (Pt 2):347-353. [pdf]
Levak-Frank S, Hofmann W, Weinstock PH, Radner H, Sattler W, Breslow JL, Zechner R. (1999) Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels. Proc. Natl. Acad. Sci. USA, 96(6):3165-3170. [pdf]
Weinstock PH, Levak-Frank S, Hudgins LC, Radner H, Friedman JM, Zechner R, Breslow JL. (1997) Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc. Natl. Acad. Sci. USA, 94(19):10261-10266. [pdf]
Levak-Frank S, Weinstock PH, Hayek T, Verdery R, Hofmann W, Ramakrishnan R, Sattler W, Breslow JL, Zechner R. (1997) Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma. J. Biol. Chem., 272(27):17182-17190. [pdf]
Hoefler G, Noehammer C, Levak-Frank S, el-Shabrawi Y, Schauer S, Zechner R, Radner H. (1997) Muscle-specific overexpression of human lipoprotein lipase in mice causes increased intracellular free fatty acids and induction of peroxisomal enzymes. Biochimie, 79(2-3):163-168. [Abstract]
Panzenboeck U, Wintersberger A, Levak-Frank S, Zimmermann R, Zechner R, Kostner GM, Malle E, Sattler W. (1997) Implications of endogenous and exogenous lipoprotein lipase for the selective uptake of HDL3-associated cholesteryl esters by mouse peritoneal macrophages. J. Lipid Res., 38(2):239-253. [pdf]
Sattler W, Levak-Frank S, Radner H, Kostner GM, Zechner R. (1996) Muscle-specific overexpression of lipoprotein lipase in transgenic mice results in increased alpha-tocopherol levels in skeletal muscle. Biochem. J., 318 (Pt 1):15-19. [pdf]
Weinstock PH, Bisgaier CL, Aalto-Setala K, Radner H, Ramakrishnan R, Levak-Frank S, Essenburg AD, Zechner R, Breslow JL. (1995) Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. J. Clin. Invest., 96(6):2555-2568. [pdf]
Levak-Frank S, Radner H, Walsh A, Stollberger R, Knipping G, Hoefler G, Sattler W, Weinstock PH, Breslow JL, Zechner R. (1995) Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J. Clin. Invest., 96(2):976-986. [pdf]
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